TP53 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TP53-specific vectors and viral particles designed for reliable TP53 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TP53 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TP53 Gene Overview
| Gene Name | tumor protein p53 |
|---|---|
| Gene Symbol | TP53 |
| Synonyms | P53,BCC7,LFS1,BMFS5,TRP53 |
| NCBI ID | 7157 |
| Ensembl ID | ENSG00000141510 |
| Uniprot ID | P04637 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Human TP53 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC147326 | View Product |
| AAV Vector & Virus | Long-term expression | VC147326 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG247326 | View Product |
| ORF Vector | Template DNA | PC147326 | View Product |
Mouse Gene Overview
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|---|---|
| Gene Symbol | |
| Synonyms | |
| NCBI ID | |
| Ensembl ID | |
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Gene Summary
Mouse Related Products
| Product Type | Key Applications | Cat. No. | Product |
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Rat Tp53 Gene Overview
| Gene Name | tumor protein p53 |
|---|---|
| Gene Symbol | Tp53 |
| Synonyms | p53,Trp53 |
| NCBI ID | 246334 |
| Ensembl ID | ENSRNOG00000010756 |
| Uniprot ID | P10361 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, May 2024]
Rat Tp53 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC647326 | View Product |
| AAV Vector & Virus | Long-term expression | VC647326 | View Product |
| Adenovirus | Transient expression | A647326 | View Product |
| CRISPR KO Tools | Gene knockout (AAV) | VG647326 | View Product |
| CRISPR Activation | Gene activation | LA647326 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS647326 | View Product |
| Gene knockdown (AAV) | VS647326 | View Product | |
| ORF Vector | Template DNA | PC647326 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |