TRAF2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TRAF2-specific vectors and viral particles designed for reliable TRAF2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TRAF2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TRAF2 Gene Overview
| Gene Name | TNF receptor associated factor 2 |
|---|---|
| Gene Symbol | TRAF2 |
| Synonyms | TRAP,TRAP3,RNF117,MGC:45012 |
| NCBI ID | 7186 |
| Ensembl ID | ENSG00000127191 |
| Uniprot ID | Q12933 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Human TRAF2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC147429 | View Product |
| AAV Vector & Virus | Long-term expression | VC147429 | View Product |
| Adenovirus | Transient expression | A147429 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG147429 | View Product |
| Gene knockout (non-viral) | PG147429 | View Product | |
| Gene knockout (AAV) | VG147429 | View Product | |
| CRISPR Activation | Gene activation | LA147429 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS147429 | View Product |
| Gene knockdown (AAV) | VS147429 | View Product | |
| ORF Vector | Template DNA | PC147429 | View Product |
Mouse Traf2 Gene Overview
| Gene Name | TNF receptor-associated factor 2 |
|---|---|
| Gene Symbol | Traf2 |
| Synonyms | |
| NCBI ID | 22030 |
| Ensembl ID | ENSMUSG00000026942 |
| Uniprot ID | P39429 |
| Gene Type | Protein coding |
Gene Summary
Enables CD40 receptor binding activity; signaling adaptor activity; and ubiquitin protein ligase activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including canonical NF-kappaB signal transduction; cellular response to nitric oxide; and regulation of intracellular signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; liver; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Traf2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC447429 | View Product |
| AAV Vector & Virus | Long-term expression | VC447429 | View Product |
| Adenovirus | Transient expression | A447429 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG447429 | View Product |
| Gene knockout (non-viral) | PG447429 | View Product | |
| Gene knockout (AAV) | VG447429 | View Product | |
| CRISPR Activation | Gene activation | LA447429 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS447429 | View Product |
| Gene knockdown (AAV) | VS447429 | View Product | |
| ORF Vector | Template DNA | PC447429 | View Product |
Rat Traf2 Gene Overview
| Gene Name | Tnf receptor-associated factor 2 |
|---|---|
| Gene Symbol | Traf2 |
| Synonyms | |
| NCBI ID | 311786 |
| Ensembl ID | ENSRNOG00000006238 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex. Part of protein-containing complex. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Traf2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |