TREM2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TREM2-specific vectors and viral particles designed for reliable TREM2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TREM2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TREM2 Gene Overview
| Gene Name | triggering receptor expressed on myeloid cells 2 |
|---|---|
| Gene Symbol | TREM2 |
| Synonyms | AD17,PLOSL2,TREM-2,Trem2a,Trem2b,Trem2c |
| NCBI ID | 54209 |
| Ensembl ID | ENSG00000095970 |
| Uniprot ID | Q9NZC2 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Human TREM2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC147700 | View Product |
| AAV Vector & Virus | Long-term expression | VC147700 | View Product |
| Adenovirus | Transient expression | A147700 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG147700 | View Product |
| Gene knockout (non-viral) | PG147700 | View Product | |
| Gene knockout (AAV) | VG147700 | View Product | |
| CRISPR Activation | Gene activation | LA147700 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS147700 | View Product |
| Gene knockdown (AAV) | VS147700 | View Product | |
| ORF Vector | Template DNA | PC147700 | View Product |
Mouse Trem2 Gene Overview
| Gene Name | triggering receptor expressed on myeloid cells 2 |
|---|---|
| Gene Symbol | Trem2 |
| Synonyms | TREM-2,Trem2a,Trem2b,Trem2c |
| NCBI ID | 83433 |
| Ensembl ID | ENSMUSG00000023992 |
| Uniprot ID | Q99NH8 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Mouse Trem2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC447700 | View Product |
| AAV Vector & Virus | Long-term expression | VC447700 | View Product |
| Adenovirus | Transient expression | A447700 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG447700 | View Product |
| Gene knockout (non-viral) | PG447700 | View Product | |
| Gene knockout (AAV) | VG447700 | View Product | |
| CRISPR Activation | Gene activation | LA447700 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS447700 | View Product |
| Gene knockdown (AAV) | VS447700 | View Product | |
| ORF Vector | Template DNA | PC447700 | View Product |
Rat Trem2 Gene Overview
| Gene Name | triggering receptor expressed on myeloid cells 2 |
|---|---|
| Gene Symbol | Trem2 |
| Synonyms | Trem2-Mia,Trem2-Mib |
| NCBI ID | 301227 |
| Ensembl ID | ENSRNOG00000013578 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 17. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Trem2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC647700 | View Product |
| AAV Vector & Virus | Long-term expression | VC647700 | View Product |
| Adenovirus | Transient expression | A647700 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG647700 | View Product |
| Gene knockout (non-viral) | PG647700 | View Product | |
| Gene knockout (AAV) | VG647700 | View Product | |
| CRISPR Activation | Gene activation | LA647700 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS647700 | View Product |
| Gene knockdown (AAV) | VS647700 | View Product | |
| ORF Vector | Template DNA | PC647700 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |