TRPV4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TRPV4-specific vectors and viral particles designed for reliable TRPV4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TRPV4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TRPV4 Gene Overview
| Gene Name | transient receptor potential cation channel subfamily V member 4 |
|---|---|
| Gene Symbol | TRPV4 |
| Synonyms | SMAL,VRL2,BCYM3,CMT2C,SPSMA,TRP12,VROAC,HMSN2C,OTRPC4,SSQTL1 |
| NCBI ID | 59341 |
| Ensembl ID | ENSG00000111199 |
| Uniprot ID | Q9HBA0 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Human TRPV4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC148533 | View Product |
| AAV Vector & Virus | Long-term expression | VC148533 | View Product |
| Adenovirus | Transient expression | A148533 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG148533 | View Product |
| Gene knockout (non-viral) | PG148533 | View Product | |
| Gene knockout (AAV) | VG148533 | View Product | |
| CRISPR Activation | Gene activation | LA148533 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS148533 | View Product |
| Gene knockdown (AAV) | VS148533 | View Product | |
| ORF Vector | Template DNA | PC148533 | View Product |
Mouse Trpv4 Gene Overview
| Gene Name | transient receptor potential cation channel, subfamily V, member 4 |
|---|---|
| Gene Symbol | Trpv4 |
| Synonyms | Trp12,VRL-2,VROAC,OTRPC4,VR-OAC,0610033B08Rik |
| NCBI ID | 63873 |
| Ensembl ID | ENSMUSG00000014158 |
| Uniprot ID | Q9EPK8 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including SH2 domain binding activity; calcium channel activity; and osmosensor activity. Involved in several processes, including cellular response to osmotic stress; positive regulation of MAPK cascade; and positive regulation of cytokine production. Acts upstream of or within hyperosmotic salinity response; regulation of response to osmotic stress; and vasopressin secretion. Located in adherens junction and cilium. Is active in plasma membrane. Is expressed in several structures, including brain; limb; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Trpv4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC448533 | View Product |
| AAV Vector & Virus | Long-term expression | VC448533 | View Product |
| Adenovirus | Transient expression | A448533 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG448533 | View Product |
| Gene knockout (non-viral) | PG448533 | View Product | |
| Gene knockout (AAV) | VG448533 | View Product | |
| CRISPR Activation | Gene activation | LA448533 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS448533 | View Product |
| Gene knockdown (AAV) | VS448533 | View Product | |
| ORF Vector | Template DNA | PC448533 | View Product |
Rat Trpv4 Gene Overview
| Gene Name | transient receptor potential cation channel, subfamily V, member 4 |
|---|---|
| Gene Symbol | Trpv4 |
| Synonyms | Vroac,Otrpc4 |
| NCBI ID | 66026 |
| Ensembl ID | ENSRNOG00000001195 |
| Uniprot ID | Q9ERZ8 |
| Gene Type | Protein coding |
Gene Summary
Enables calcium channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including cytoskeleton; focal adhesion; and ruffle membrane. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Trpv4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC648533 | View Product |
| AAV Vector & Virus | Long-term expression | VC648533 | View Product |
| Adenovirus | Transient expression | A648533 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG648533 | View Product |
| Gene knockout (non-viral) | PG648533 | View Product | |
| Gene knockout (AAV) | VG648533 | View Product | |
| CRISPR Activation | Gene activation | LA648533 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS648533 | View Product |
| Gene knockdown (AAV) | VS648533 | View Product | |
| ORF Vector | Template DNA | PC648533 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |