TSC1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TSC1-specific vectors and viral particles designed for reliable TSC1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TSC1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TSC1 Gene Overview
| Gene Name | TSC complex subunit 1 |
|---|---|
| Gene Symbol | TSC1 |
| Synonyms | LAM,TSC |
| NCBI ID | 7248 |
| Ensembl ID | ENSG00000165699 |
| Uniprot ID | Q92574 |
| Gene Type | Protein coding |
Gene Summary
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
Human TSC1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC142234 | View Product |
| Stable overexpression | LC148543 | View Product | |
| AAV Vector & Virus | Long-term expression | VC142234 | View Product |
| Long-term expression | VC148543 | View Product | |
| Adenovirus | Transient expression | A142234 | View Product |
| Transient expression | A148543 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG148543 | View Product |
| Gene knockout (non-viral) | PG148543 | View Product | |
| Gene knockout (AAV) | VG148543 | View Product | |
| CRISPR Activation | Gene activation | LA148543 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS148543 | View Product |
| Gene knockdown (AAV) | VS148543 | View Product | |
| ORF Vector | Template DNA | PC142234 | View Product |
| Template DNA | PC148543 | View Product |
Mouse Tsc1 Gene Overview
| Gene Name | TSC complex subunit 1 |
|---|---|
| Gene Symbol | Tsc1 |
| Synonyms | |
| NCBI ID | 64930 |
| Ensembl ID | ENSMUSG00000026812 |
| Uniprot ID | Q9EP53 |
| Gene Type | Protein coding |
Gene Summary
Enables ATPase inhibitor activity. Involved in associative learning; negative regulation of ATP-dependent activity; and protein stabilization. Acts upstream of or within several processes, including memory T cell differentiation; negative regulation of cell size; and nervous system development. Located in cytoplasm. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; hepatic primordium; liver; and retina. Used to study anterior segment dysgenesis; autism spectrum disorder; autosomal recessive polycystic kidney disease; spinal disease; and tuberous sclerosis. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tsc1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC448543 | View Product |
| Adenovirus | Transient expression | A448543 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG448543 | View Product |
| Gene knockout (non-viral) | PG448543 | View Product | |
| Gene knockout (AAV) | VG448543 | View Product | |
| CRISPR Activation | Gene activation | LA448543 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS448543 | View Product |
| Gene knockdown (AAV) | VS448543 | View Product | |
| ORF Vector | Template DNA | PC448543 | View Product |
Rat Tsc1 Gene Overview
| Gene Name | TSC complex subunit 1 |
|---|---|
| Gene Symbol | Tsc1 |
| Synonyms | |
| NCBI ID | 60445 |
| Ensembl ID | ENSRNOG00000011470 |
| Uniprot ID | Q9Z136 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable ATPase inhibitor activity; heat shock protein binding activity; and protein folding chaperone. Involved in several processes, including negative regulation of GTPase activity; positive regulation of stress fiber assembly; and regulation of macroautophagy. Located in growth cone; nucleus; and perinuclear region of cytoplasm. Used to study obesity. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tsc1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC648543 | View Product |
| Adenovirus | Transient expression | A648543 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG648543 | View Product |
| Gene knockout (non-viral) | PG648543 | View Product | |
| Gene knockout (AAV) | VG648543 | View Product | |
| CRISPR Activation | Gene activation | LA648543 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS648543 | View Product |
| Gene knockdown (AAV) | VS648543 | View Product | |
| ORF Vector | Template DNA | PC648543 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |