TSC2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TSC2-specific vectors and viral particles designed for reliable TSC2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TSC2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TSC2 Gene Overview
| Gene Name | TSC complex subunit 2 |
|---|---|
| Gene Symbol | TSC2 |
| Synonyms | LAM,TSC4,PPP1R160 |
| NCBI ID | 7249 |
| Ensembl ID | ENSG00000103197 |
| Uniprot ID | P49815 |
| Gene Type | Protein coding |
Gene Summary
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
Human TSC2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A148544 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG148544 | View Product |
| Gene knockout (non-viral) | PG148544 | View Product | |
| Gene knockout (AAV) | VG148544 | View Product | |
| CRISPR Activation | Gene activation | LA148544 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS148544 | View Product |
| Gene knockdown (AAV) | VS148544 | View Product | |
| ORF Vector | Template DNA | PC148544 | View Product |
Mouse Tsc2 Gene Overview
| Gene Name | TSC complex subunit 2 |
|---|---|
| Gene Symbol | Tsc2 |
| Synonyms | Tcs2,Nafld |
| NCBI ID | 22084 |
| Ensembl ID | ENSMUSG00000002496 |
| Uniprot ID | Q61037 |
| Gene Type | Protein coding |
Gene Summary
Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; negative regulation of lymphocyte proliferation; and regulation of signal transduction. Located in cytoplasm. Part of TSC1-TSC2 complex. Is active in lysosomal membrane and synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tsc2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A448544 | View Product |
| Transient expression | A548544 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG448544 | View Product |
| Gene knockout (non-viral) | PG448544 | View Product | |
| Gene knockout (AAV) | VG448544 | View Product | |
| CRISPR Activation | Gene activation | LA448544 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS448544 | View Product |
| Gene knockdown (AAV) | VS448544 | View Product | |
| ORF Vector | Template DNA | PC448544 | View Product |
| Template DNA | PC548544 | View Product |
Rat Tsc2 Gene Overview
| Gene Name | TSC complex subunit 2 |
|---|---|
| Gene Symbol | Tsc2 |
| Synonyms | Rc |
| NCBI ID | 24855 |
| Ensembl ID | ENSRNOG00000011375 |
| Uniprot ID | P49816 |
| Gene Type | Protein coding |
Gene Summary
Enables GTPase activator activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of signal transduction; and regulation of neuron projection development. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including caveola; growth cone; and neuronal cell body. Is active in glutamatergic synapse. Used to study autism spectrum disorder; hepatic angiomyolipoma; and renal cell carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tsc2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A648544 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG648544 | View Product |
| Gene knockout (non-viral) | PG648544 | View Product | |
| Gene knockout (AAV) | VG648544 | View Product | |
| CRISPR Activation | Gene activation | LA648544 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS648544 | View Product |
| Gene knockdown (AAV) | VS648544 | View Product | |
| ORF Vector | Template DNA | PC648544 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |