TYROBP Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TYROBP-specific vectors and viral particles designed for reliable TYROBP overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TYROBP CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TYROBP Gene Overview
| Gene Name | transmembrane immune signaling adaptor TYROBP |
|---|---|
| Gene Symbol | TYROBP |
| Synonyms | DAP12,KARAP,PLOSL,PLOSL1 |
| NCBI ID | 7305 |
| Ensembl ID | ENSG00000011600 |
| Uniprot ID | O43914 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Human TYROBP Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC148895 | View Product |
| AAV Vector & Virus | Long-term expression | VC148895 | View Product |
| Adenovirus | Transient expression | A148895 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG148895 | View Product |
| Gene knockout (non-viral) | PG148895 | View Product | |
| Gene knockout (AAV) | VG148895 | View Product | |
| CRISPR Activation | Gene activation | LA148895 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS148895 | View Product |
| Gene knockdown (AAV) | VS148895 | View Product | |
| ORF Vector | Template DNA | PC148895 | View Product |
Mouse Tyrobp Gene Overview
| Gene Name | TYRO protein tyrosine kinase binding protein |
|---|---|
| Gene Symbol | Tyrobp |
| Synonyms | Ly83,DAP12,KARAP |
| NCBI ID | 22177 |
| Ensembl ID | ENSMUSG00000030579 |
| Uniprot ID | O54885 |
| Gene Type | Protein coding |
Gene Summary
Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tyrobp Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC448895 | View Product |
| AAV Vector & Virus | Long-term expression | VC448895 | View Product |
| Adenovirus | Transient expression | A448895 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG448895 | View Product |
| Gene knockout (non-viral) | PG448895 | View Product | |
| Gene knockout (AAV) | VG448895 | View Product | |
| CRISPR Activation | Gene activation | LA448895 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS448895 | View Product |
| Gene knockdown (AAV) | VS448895 | View Product | |
| ORF Vector | Template DNA | PC448895 | View Product |
Rat Tyrobp Gene Overview
| Gene Name | transmembrane immune signaling adaptor Tyrobp |
|---|---|
| Gene Symbol | Tyrobp |
| Synonyms | Karap |
| NCBI ID | 361537 |
| Ensembl ID | |
| Uniprot ID | Q6X9T7 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable protein homodimerization activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of cytokine production. Predicted to act upstream of or within osteoclast differentiation and regulation of osteoclast development. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Apr 2025]
Rat Tyrobp Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC648895 | View Product |
| AAV Vector & Virus | Long-term expression | VC648895 | View Product |
| Adenovirus | Transient expression | A648895 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG648895 | View Product |
| Gene knockout (non-viral) | PG648895 | View Product | |
| Gene knockout (AAV) | VG648895 | View Product | |
| CRISPR Activation | Gene activation | LA648895 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS648895 | View Product |
| Gene knockdown (AAV) | VS648895 | View Product | |
| ORF Vector | Template DNA | PC648895 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |