VDR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use VDR-specific vectors and viral particles designed for reliable VDR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including VDR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human VDR Gene Overview
| Gene Name | vitamin D receptor |
|---|---|
| Gene Symbol | VDR |
| Synonyms | NR1I1,PPP1R163 |
| NCBI ID | 7421 |
| Ensembl ID | ENSG00000111424 |
| Uniprot ID | P11473 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
Human VDR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC149475 | View Product |
| AAV Vector & Virus | Long-term expression | VC149475 | View Product |
| Adenovirus | Transient expression | A149475 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG149475 | View Product |
| Gene knockout (non-viral) | PG149475 | View Product | |
| Gene knockout (AAV) | VG149475 | View Product | |
| CRISPR Activation | Gene activation | LA149475 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS149475 | View Product |
| Gene knockdown (AAV) | VS149475 | View Product | |
| ORF Vector | Template DNA | PC149475 | View Product |
Mouse Vdr Gene Overview
| Gene Name | vitamin D (1,25-dihydroxyvitamin D3) receptor |
|---|---|
| Gene Symbol | Vdr |
| Synonyms | Nr1i1 |
| NCBI ID | 22337 |
| Ensembl ID | ENSMUSG00000022479 |
| Uniprot ID | P48281 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Vdr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC449475 | View Product |
| AAV Vector & Virus | Long-term expression | VC449475 | View Product |
| Adenovirus | Transient expression | A449475 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG449475 | View Product |
| Gene knockout (non-viral) | PG449475 | View Product | |
| Gene knockout (AAV) | VG449475 | View Product | |
| CRISPR Activation | Gene activation | LA449475 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS449475 | View Product |
| Gene knockdown (AAV) | VS449475 | View Product | |
| ORF Vector | Template DNA | PC449475 | View Product |
Rat Vdr Gene Overview
| Gene Name | vitamin D receptor |
|---|---|
| Gene Symbol | Vdr |
| Synonyms | Nr1i1 |
| NCBI ID | 24873 |
| Ensembl ID | ENSRNOG00000054420 |
| Uniprot ID | P13053 |
| Gene Type | Protein coding |
Gene Summary
Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Used to study vitamin D-dependent rickets type 2A. Biomarker of retinal degeneration and secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Vdr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC649475 | View Product |
| AAV Vector & Virus | Long-term expression | VC649475 | View Product |
| Adenovirus | Transient expression | A649475 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG649475 | View Product |
| Gene knockout (non-viral) | PG649475 | View Product | |
| Gene knockout (AAV) | VG649475 | View Product | |
| CRISPR Activation | Gene activation | LA649475 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS649475 | View Product |
| Gene knockdown (AAV) | VS649475 | View Product | |
| ORF Vector | Template DNA | PC649475 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |