VEGFA Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use VEGFA-specific vectors and viral particles designed for reliable VEGFA overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including VEGFA CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human VEGFA Gene Overview
| Gene Name | vascular endothelial growth factor A |
|---|---|
| Gene Symbol | VEGFA |
| Synonyms | VPF,VEGF,MVCD1,L-VEGF |
| NCBI ID | 7422 |
| Ensembl ID | ENSG00000112715 |
| Uniprot ID | P15692 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020]
Human VEGFA Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC149476 | View Product |
| AAV Vector & Virus | Long-term expression | VC149476 | View Product |
| Adenovirus | Transient expression | A149476 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG149476 | View Product |
| Gene knockout (non-viral) | PG149476 | View Product | |
| Gene knockout (AAV) | VG149476 | View Product | |
| CRISPR Activation | Gene activation | LA149476 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS149476 | View Product |
| Gene knockdown (AAV) | VS149476 | View Product | |
| ORF Vector | Template DNA | PC149476 | View Product |
Mouse Vegfa Gene Overview
| Gene Name | vascular endothelial growth factor A |
|---|---|
| Gene Symbol | Vegfa |
| Synonyms | Vpf,Vegf,L-VEGF |
| NCBI ID | 22339 |
| Ensembl ID | ENSMUSG00000023951 |
| Uniprot ID | Q00731 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]
Mouse Vegfa Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC449476 | View Product |
| Stable overexpression | LC549476 | View Product | |
| AAV Vector & Virus | Long-term expression | VC449476 | View Product |
| Long-term expression | VC549476 | View Product | |
| Adenovirus | Transient expression | A449476 | View Product |
| Transient expression | A549476 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG449476 | View Product |
| Gene knockout (non-viral) | PG449476 | View Product | |
| Gene knockout (AAV) | VG449476 | View Product | |
| CRISPR Activation | Gene activation | LA449476 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS449476 | View Product |
| Gene knockdown (AAV) | VS449476 | View Product | |
| ORF Vector | Template DNA | PC449476 | View Product |
| Template DNA | PC549476 | View Product |
Rat Vegfa Gene Overview
| Gene Name | vascular endothelial growth factor A |
|---|---|
| Gene Symbol | Vegfa |
| Synonyms | VPF,Vegf,VEGF-A,VEGF111,VEGF164 |
| NCBI ID | 83785 |
| Ensembl ID | ENSRNOG00000019598 |
| Uniprot ID | P16612 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Rat Vegfa Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC649476 | View Product |
| Stable overexpression | LC749476 | View Product | |
| AAV Vector & Virus | Long-term expression | VC649476 | View Product |
| Long-term expression | VC749476 | View Product | |
| Adenovirus | Transient expression | A649476 | View Product |
| Transient expression | A749476 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG649476 | View Product |
| Gene knockout (non-viral) | PG649476 | View Product | |
| Gene knockout (AAV) | VG649476 | View Product | |
| CRISPR Activation | Gene activation | LA649476 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS649476 | View Product |
| Gene knockdown (AAV) | VS649476 | View Product | |
| ORF Vector | Template DNA | PC649476 | View Product |
| Template DNA | PC749476 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |