VHL Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use VHL-specific vectors and viral particles designed for reliable VHL overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including VHL CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human VHL Gene Overview
| Gene Name | von Hippel-Lindau tumor suppressor |
|---|---|
| Gene Symbol | VHL |
| Synonyms | RCA1,VHL1,pVHL,HRCA1 |
| NCBI ID | 7428 |
| Ensembl ID | ENSG00000134086 |
| Uniprot ID | P40337 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]
Human VHL Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC149498 | View Product |
| AAV Vector & Virus | Long-term expression | VC149498 | View Product |
| Adenovirus | Transient expression | A249498 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG149498 | View Product |
| Gene knockout (non-viral) | PG149498 | View Product | |
| Gene knockout (AAV) | VG149498 | View Product | |
| CRISPR Activation | Gene activation | LA149498 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS149498 | View Product |
| Gene knockdown (AAV) | VS149498 | View Product | |
| ORF Vector | Template DNA | PC149498 | View Product |
Mouse Vhl Gene Overview
| Gene Name | von Hippel-Lindau tumor suppressor |
|---|---|
| Gene Symbol | Vhl |
| Synonyms | Vhlh,pVHL |
| NCBI ID | 22346 |
| Ensembl ID | ENSMUSG00000033933 |
| Uniprot ID | P40338 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including DNA-binding transcription factor binding activity; transcription elongation factor activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in regulation of postsynapse organization and regulation protein catabolic process at postsynapse. Acts upstream of or within several processes, including camera-type eye morphogenesis; endocrine pancreas development; and regulation of apoptotic process. Located in cilium; cytoplasm; and nuclear lumen. Part of Cul2-RING ubiquitin ligase complex. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including extraembryonic component; eye; genitourinary system; gut; and nervous system. Used to study familial erythrocytosis 2; sudden infant death syndrome; and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHL (von Hippel-Lindau tumor suppressor). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Vhl Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC449498 | View Product |
| AAV Vector & Virus | Long-term expression | VC449498 | View Product |
| Adenovirus | Transient expression | A449498 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG449498 | View Product |
| Gene knockout (non-viral) | PG449498 | View Product | |
| Gene knockout (AAV) | VG449498 | View Product | |
| CRISPR Activation | Gene activation | LA449498 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS449498 | View Product |
| Gene knockdown (AAV) | VS449498 | View Product | |
| ORF Vector | Template DNA | PC449498 | View Product |
Rat Vhl Gene Overview
| Gene Name | von Hippel-Lindau tumor suppressor |
|---|---|
| Gene Symbol | Vhl |
| Synonyms | Vhlh |
| NCBI ID | 24874 |
| Ensembl ID | ENSRNOG00000010258 |
| Uniprot ID | Q64259 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including protein serine/threonine kinase binding activity; transcription elongation factor activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including regulation of primary metabolic process; response to ethanol; and response to hypoxia. Part of VCB complex. Used to study Parkinsonism. Biomarker of nephroblastoma and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHL (von Hippel-Lindau tumor suppressor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Vhl Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC649498 | View Product |
| AAV Vector & Virus | Long-term expression | VC649498 | View Product |
| Adenovirus | Transient expression | A649498 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG649498 | View Product |
| Gene knockout (non-viral) | PG649498 | View Product | |
| Gene knockout (AAV) | VG649498 | View Product | |
| CRISPR Activation | Gene activation | LA649498 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS649498 | View Product |
| Gene knockdown (AAV) | VS649498 | View Product | |
| ORF Vector | Template DNA | PC649498 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |