WNK1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use WNK1-specific vectors and viral particles designed for reliable WNK1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including WNK1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human WNK1 Gene Overview
| Gene Name | WNK lysine deficient protein kinase 1 |
|---|---|
| Gene Symbol | WNK1 |
| Synonyms | KDP,PSK,p65,HSN2,HSAN2,PRKWNK1,PPP1R167 |
| NCBI ID | 65125 |
| Ensembl ID | ENSG00000060237 |
| Uniprot ID | Q9H4A3 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Human WNK1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A150439 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG150439 | View Product |
| Gene knockout (non-viral) | PG150439 | View Product | |
| Gene knockout (AAV) | VG150439 | View Product | |
| CRISPR Activation | Gene activation | LA150439 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS150439 | View Product |
| Gene knockdown (AAV) | VS150439 | View Product | |
| ORF Vector | Template DNA | PC150439 | View Product |
Mouse Wnk1 Gene Overview
| Gene Name | WNK lysine deficient protein kinase 1 |
|---|---|
| Gene Symbol | Wnk1 |
| Synonyms | Hsn2,Prkwnk1,EG406236,mKIAA0344,6430573H23Rik |
| NCBI ID | 232341 |
| Ensembl ID | ENSMUSG00000045962 |
| Uniprot ID | P83741 |
| Gene Type | Protein coding |
Gene Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular chloride ion homeostasis; and lymphocyte migration into lymph node. Acts upstream of or within several processes, including negative regulation of pancreatic juice secretion; negative regulation of small GTPase mediated signal transduction; and protein phosphorylation. Part of protein-containing complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Wnk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG450439 | View Product |
| Gene knockout (non-viral) | PG450439 | View Product | |
| Gene knockout (AAV) | VG450439 | View Product | |
| CRISPR Activation | Gene activation | LA450439 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS450439 | View Product |
| Gene knockdown (AAV) | VS450439 | View Product | |
| ORF Vector | Template DNA | PC450439 | View Product |
| Template DNA | PC550439 | View Product |
Rat Wnk1 Gene Overview
| Gene Name | WNK lysine deficient protein kinase 1 |
|---|---|
| Gene Symbol | Wnk1 |
| Synonyms | Hsn2,Prkwnk1 |
| NCBI ID | 116477 |
| Ensembl ID | ENSRNOG00000009956 |
| Uniprot ID | Q9JIH7 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ATP binding activity; magnesium ion binding activity; and molecular condensate scaffold activity. Involved in several processes, including cell volume homeostasis; cellular hyperosmotic response; and negative regulation of protein localization to plasma membrane. Located in cytosol and membrane. Is active in GABA-ergic synapse and intracellular membraneless organelle. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Wnk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG650439 | View Product |
| Gene knockout (non-viral) | PG650439 | View Product | |
| Gene knockout (AAV) | VG650439 | View Product | |
| CRISPR Activation | Gene activation | LA650439 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS650439 | View Product |
| Gene knockdown (AAV) | VS650439 | View Product | |
| ORF Vector | Template DNA | PC650439 | View Product |
| Template DNA | PC750439 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |