WWOX Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use WWOX-specific vectors and viral particles designed for reliable WWOX overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including WWOX CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human WWOX Gene Overview
| Gene Name | WW domain containing oxidoreductase |
|---|---|
| Gene Symbol | WWOX |
| Synonyms | FOR,WOX1,DEE28,EIEE28,FRA16D,SCAR12,HHCMA56,PRO0128,SDR41C1,D16S432E |
| NCBI ID | 51741 |
| Ensembl ID | ENSG00000186153 |
| Uniprot ID | Q9NZC7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Human WWOX Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC150486 | View Product |
| AAV Vector & Virus | Long-term expression | VC150486 | View Product |
| Adenovirus | Transient expression | A150486 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG150486 | View Product |
| Gene knockout (non-viral) | PG150486 | View Product | |
| Gene knockout (AAV) | VG150486 | View Product | |
| CRISPR Activation | Gene activation | LA150486 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS150486 | View Product |
| Gene knockdown (AAV) | VS150486 | View Product | |
| ORF Vector | Template DNA | PC150486 | View Product |
Mouse Wwox Gene Overview
| Gene Name | WW domain-containing oxidoreductase |
|---|---|
| Gene Symbol | Wwox |
| Synonyms | WOX1,5330426P09Rik,9030416C10Rik |
| NCBI ID | 80707 |
| Ensembl ID | ENSMUSG00000004637 |
| Uniprot ID | Q91WL8 |
| Gene Type | Protein coding |
Gene Summary
Enables enzyme binding activity. Contributes to transcription coactivator activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of extrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in mitochondrion and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and skeleton. Used to study autosomal recessive spinocerebellar ataxia 12. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Wwox Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC450486 | View Product |
| AAV Vector & Virus | Long-term expression | VC450486 | View Product |
| Adenovirus | Transient expression | A450486 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG450486 | View Product |
| Gene knockout (non-viral) | PG450486 | View Product | |
| Gene knockout (AAV) | VG450486 | View Product | |
| CRISPR Activation | Gene activation | LA450486 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS450486 | View Product |
| Gene knockdown (AAV) | VS450486 | View Product | |
| ORF Vector | Template DNA | PC450486 | View Product |
Rat Wwox Gene Overview
| Gene Name | WW domain-containing oxidoreductase |
|---|---|
| Gene Symbol | Wwox |
| Synonyms | |
| NCBI ID | 292041 |
| Ensembl ID | ENSRNOG00000012030 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable enzyme binding activity and identical protein binding activity. Predicted to contribute to transcription coactivator activity. Predicted to be involved in cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including Golgi apparatus; microvillus; and mitochondrion. Predicted to be part of RNA polymerase II transcription regulator complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Wwox Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC650486 | View Product |
| AAV Vector & Virus | Long-term expression | VC650486 | View Product |
| Adenovirus | Transient expression | A650486 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG650486 | View Product |
| Gene knockout (non-viral) | PG650486 | View Product | |
| Gene knockout (AAV) | VG650486 | View Product | |
| CRISPR Activation | Gene activation | LA650486 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS650486 | View Product |
| Gene knockdown (AAV) | VS650486 | View Product | |
| ORF Vector | Template DNA | PC650486 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |