XBP1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use XBP1-specific vectors and viral particles designed for reliable XBP1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including XBP1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human XBP1 Gene Overview
| Gene Name | X-box binding protein 1 |
|---|---|
| Gene Symbol | XBP1 |
| Synonyms | XBP2,TREB5,XBP-1,TREB-5 |
| NCBI ID | 7494 |
| Ensembl ID | ENSG00000100219 |
| Uniprot ID | P17861 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Human XBP1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC150505 | View Product |
| AAV Vector & Virus | Long-term expression | VC150505 | View Product |
| Adenovirus | Transient expression | A150505 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG150505 | View Product |
| Gene knockout (non-viral) | PG150505 | View Product | |
| Gene knockout (AAV) | VG150505 | View Product | |
| CRISPR Activation | Gene activation | LA150505 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS150505 | View Product |
| Gene knockdown (AAV) | VS150505 | View Product | |
| ORF Vector | Template DNA | PC150505 | View Product |
Mouse Xbp1 Gene Overview
| Gene Name | X-box binding protein 1 |
|---|---|
| Gene Symbol | Xbp1 |
| Synonyms | TREB5,XBP-1,TREB-5,D11Ertd39e |
| NCBI ID | 22433 |
| Ensembl ID | ENSMUSG00000020484 |
| Uniprot ID | O35426 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including cellular response to hexose stimulus; intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; epithelial cell maturation; and regulation of protein metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeletal system. Used to study inflammatory bowel disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Xbp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC450505 | View Product |
| AAV Vector & Virus | Long-term expression | VC450505 | View Product |
| Adenovirus | Transient expression | A450505 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG450505 | View Product |
| Gene knockout (non-viral) | PG450505 | View Product | |
| Gene knockout (AAV) | VG450505 | View Product | |
| CRISPR Activation | Gene activation | LA450505 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS450505 | View Product |
| Gene knockdown (AAV) | VS450505 | View Product | |
| ORF Vector | Template DNA | PC450505 | View Product |
Rat Xbp1 Gene Overview
| Gene Name | X-box binding protein 1 |
|---|---|
| Gene Symbol | Xbp1 |
| Synonyms | HTF |
| NCBI ID | 289754 |
| Ensembl ID | ENSRNOG00000010298 |
| Uniprot ID | Q9R1S4 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and serotonin secretion, neurotransmission. Predicted to be located in cytosol and endoplasmic reticulum membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Biomarker of borna disease and metabolic dysfunction-associated steatotic liver disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Xbp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC650505 | View Product |
| AAV Vector & Virus | Long-term expression | VC650505 | View Product |
| Adenovirus | Transient expression | A650505 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG650505 | View Product |
| Gene knockout (non-viral) | PG650505 | View Product | |
| Gene knockout (AAV) | VG650505 | View Product | |
| CRISPR Activation | Gene activation | LA650505 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS650505 | View Product |
| Gene knockdown (AAV) | VS650505 | View Product | |
| ORF Vector | Template DNA | PC650505 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |