ZAP70 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ZAP70-specific vectors and viral particles designed for reliable ZAP70 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ZAP70 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ZAP70 Gene Overview
| Gene Name | zeta chain of T cell receptor associated protein kinase 70 |
|---|---|
| Gene Symbol | ZAP70 |
| Synonyms | SRK,STD,TZK,STCD,IMD48,ADMIO2,ZAP-70 |
| NCBI ID | 7535 |
| Ensembl ID | ENSG00000115085 |
| Uniprot ID | P43403 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Human ZAP70 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC150672 | View Product |
| AAV Vector & Virus | Long-term expression | VC150672 | View Product |
| Adenovirus | Transient expression | A150672 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG150672 | View Product |
| Gene knockout (non-viral) | PG150672 | View Product | |
| Gene knockout (AAV) | VG150672 | View Product | |
| CRISPR Activation | Gene activation | LA150672 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS150672 | View Product |
| Gene knockdown (AAV) | VS150672 | View Product | |
| ORF Vector | Template DNA | PC150672 | View Product |
Mouse Zap70 Gene Overview
| Gene Name | zeta-chain (TCR) associated protein kinase |
|---|---|
| Gene Symbol | Zap70 |
| Synonyms | Srk,mur,mrtle,ZAP-70 |
| NCBI ID | 22637 |
| Ensembl ID | ENSMUSG00000026117 |
| Uniprot ID | P43404 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Mouse Zap70 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC450672 | View Product |
| AAV Vector & Virus | Long-term expression | VC450672 | View Product |
| Adenovirus | Transient expression | A450672 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG450672 | View Product |
| Gene knockout (non-viral) | PG450672 | View Product | |
| Gene knockout (AAV) | VG450672 | View Product | |
| CRISPR Activation | Gene activation | LA450672 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS450672 | View Product |
| Gene knockdown (AAV) | VS450672 | View Product | |
| ORF Vector | Template DNA | PC450672 | View Product |
Rat Zap70 Gene Overview
| Gene Name | zeta chain of T cell receptor associated protein kinase 70 |
|---|---|
| Gene Symbol | Zap70 |
| Synonyms | Srk |
| NCBI ID | 301348 |
| Ensembl ID | ENSRNOG00000016995 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in immune response. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to be located in several cellular components, including cell-cell junction; immunological synapse; and membrane raft. Predicted to be part of T cell receptor complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Jul 2025]
Rat Zap70 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC650672 | View Product |
| AAV Vector & Virus | Long-term expression | VC650672 | View Product |
| Adenovirus | Transient expression | A650672 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG650672 | View Product |
| Gene knockout (non-viral) | PG650672 | View Product | |
| Gene knockout (AAV) | VG650672 | View Product | |
| CRISPR Activation | Gene activation | LA650672 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS650672 | View Product |
| Gene knockdown (AAV) | VS650672 | View Product | |
| ORF Vector | Template DNA | PC650672 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |