ZEB1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ZEB1-specific vectors and viral particles designed for reliable ZEB1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ZEB1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ZEB1 Gene Overview
| Gene Name | zinc finger E-box binding homeobox 1 |
|---|---|
| Gene ID | ZEB1 |
| Aliases | BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1 |
| NCBI ID | 6935 |
| Ensembl ID | ENSG00000148516 |
| Uniprot ID | P37275 |
| Gene Type | Protein-coding |
Gene Summary & Function
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
Human ZEB1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC150811 | View Product |
| Adenovirus | Transient expression | A150811 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG150811 | View Product |
| Gene knockout (AAV) | VG150811 | View Product | |
| Gene knockout (non-viral) | PG150811 | View Product | |
| CRISPR Activation | Gene activation | LA150811 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS150811 | View Product |
| Gene knockdown (AAV) | VS150811 | View Product | |
| Gene knockdown (Synthetic) | PS150811 | View Product | |
| ORF Vector | Template DNA | PC150811 | View Product |
Mouse Zeb1 Gene Overview
| Gene Name | zinc finger E-box binding homeobox 1 |
|---|---|
| Gene ID | Zeb1 |
| Aliases | Tw, BZP, ZEB, MEB1, Nil2, Tcf8, AREB6, TCF-8, Tcf18, Zfhep, Zfx1a, Zfhx1a, Zfx1ha, [delta]EF1, 3110032K11Rik |
| NCBI ID | 21417 |
| Ensembl ID | ENSMUSG00000024238 |
| Uniprot ID | Q64318 |
| Gene Type | Protein-coding |
Gene Summary & Function
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; negative regulation of keratinocyte proliferation; and regulation of T cell differentiation in thymus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study HTLV-1-associated myelopathy/tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
Mouse Zeb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC450811 | View Product |
| Adenovirus | Transient expression | A450811 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG450811 | View Product |
| Gene knockout (AAV) | VG450811 | View Product | |
| Gene knockout (non-viral) | PG450811 | View Product | |
| CRISPR Activation | Gene activation | LA450811 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS450811 | View Product |
| Gene knockdown (AAV) | VS450811 | View Product | |
| Gene knockdown (Synthetic) | PS450811 | View Product | |
| ORF Vector | Template DNA | PC450811 | View Product |
Rat Zeb1 Gene Overview
| Gene Name | zinc finger E-box binding homeobox 1 |
|---|---|
| Gene ID | Zeb1 |
| Aliases | Tcf8, Zfhx1a, deltaEF1 |
| NCBI ID | 25705 |
| Ensembl ID | ENSRNOG00000017863 |
| Gene Type | Protein-coding |
Gene Summary & Function
Enables chromatin binding activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; and response to activity. Predicted to be located in cytosol and nucleoplasm. Biomarker of acute myocardial infarction and rheumatic heart disease. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1)
Rat Zeb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC650811 | View Product |
| AAV Vector & Virus | Long-term expression | VC650811 | View Product |
| Adenovirus | Transient expression | A650811 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG650811 | View Product |
| Gene knockout (AAV) | VG650811 | View Product | |
| Gene knockout (non-viral) | PG650811 | View Product | |
| CRISPR Activation | Gene activation | LA650811 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS650811 | View Product |
| Gene knockdown (AAV) | VS650811 | View Product | |
| Gene knockdown (Synthetic) | PS650811 | View Product | |
| ORF Vector | Template DNA | PC650811 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |