Anti-ABCA1 Antibody
Cat. No.
G090
Unit
100 μg
Price
$231.00
| Cat. No. | G090 |
| Name | Anti-ABCA1 Antibody |
| Clone | AB.H10 |
| Category | Monoclonal Antibodies |
| Application | WB,IHC,ELISA,IP |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Human,Mouse,Other |
| Description | Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. |
| Immunogen | Peptides amino acids 1800-2260 (C-Terminal end) |
| Isotype | IgG |
| Concentration | 100ug/100ul |
| Recommended Dilutions | Starting concentration for WB is 1:1000. This antibody has been tested with direct ELISA, where a 96-well plate was coated with recombinant ABCA1 C-terminal protein. The antibody was then added to the wells and a goat anti-mouse IgG HRP conjugate was used for colour development. For ABCA1 quantification, a pair of anti-ABCA1 antibodies should be used to formulate a Sandwich ELISA and with a presence of an ABCA1 protein Standard. Optimal dilution to be determined by the end user. |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Specificity | Recognize specifically ABCA1 from human, mouse, and chicken. |
| Guarantee | abm guarantees that all our Anti-ABCA1 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. G090 |
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- Umeda, T et al. "Regulation of cholesterol efflux by amyloid beta secretion" J. Neurosci. Res. 88:1985-94 (2010). PubMed: 20155813.
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