Anti-CENP-E Antibody
Cat. No.
Y120004
Unit
100 μg
Price
$232.00
| Cat. No. | Y120004 |
| Name | Anti-CENP-E Antibody |
| Clone | CENP-E.1H12 |
| Category | Monoclonal Antibodies |
| Gene Name | CENP-E |
| Application | WB,IP,ICC/IF |
| Application Info | Titrate for optimal dilution for your application. |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Human |
| Description | CENP-E is a kinesin-like protein that localizes specifically to kinectochores where it plays a critical role in establishing the microtubule attachments between the chromosomes and the spindle. Functional studies have shown that injections of CENP-E antibodies into HeLa cells did not interfere with the progression of the cells into mitosis, but rather, arrested the cells in mitosis as they failed to align their chromosomes at the spindle equator. All cells arrested in mitosis by CENP-E antibodies eventually died by apoptosis. Thus, CENP-E is essential for the completion of mitosis, though it is not vital for the progression of cells into mitosis. Additionally, CENP-E and its motor domain provide functions that are important in maintaining stable kinetochore-microtubule connections that allow chromosomes to establish bipolar connections and to align at the spindle equator. |
| Immunogen | Recombinant CENP-E protein (human) |
| Isotype | IgG1 |
| Concentration | 100ug/100ul |
| Recommended Dilutions | Titrate for optimal dilution for your application. |
| Storage Buffer | PBS, pH 7.4 with 0.02% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human |
| Purity | Purified ascites. |
| Guarantee | abm guarantees that all our Anti-CENP-E Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y120004 |
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