Anti-CLOCK Antibody
| Cat. No. | Y058196 |
| Name | Anti-CLOCK Antibody |
| Clone | Polyclonal |
| Category | Polyclonal Antibodies |
| Gene Name | CLOCK |
| Alias | KIAA0334, KAT13D, bHLHe8 |
| Application | WB,ELISA |
| Application Info |
For research use only Peptide ELISA titer: 1:20,000-1:80,000 Western blot analysis: 1:200-500 Optimal dilutions/concentrations should be determined by the end use. |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human,Mouse,Rat |
| Description |
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Immunogen | Synthetic peptide conjugated to KLH |
| Isotype | Rabbit IgG |
| Concentration | 100ug/100ul |
| Recommended Dilutions |
For research use only Peptide ELISA titer: 1:20,000-1:80,000 Western blot analysis: 1:200-500 Optimal dilutions/concentrations should be determined by the end use. |
| Storage Buffer | PBS, pH 7.4 with 0.02% Sodium Azide |
| Storage Condition |
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human,Mouse,Rat |
| Specificity | Not yet tested in other species. |
| Purity | Affinity purified |
| Guarantee |
abm guarantees that all our Anti-CLOCK ) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y058196 |