Anti-MSH2 Antibody
Cat. No.
Y050845
Unit
100 μg
Price
$486.00
| Cat. No. | Y050845 |
| Name | Anti-MSH2 Antibody |
| Clone | Monoclonal |
| Category | Monoclonal Antibodies |
| Gene Name | MSH2 |
| Alias | HNPCC, HNPCC1 |
| Application | WB,IHC,ELISA |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Human |
| Description | MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. |
| Immunogen | Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3). |
| Isotype | IgG1 |
| Concentration | 1ug/ul |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human |
| Purity | purified by protein G affinity chromatography |
| Guarantee | abm guarantees that all our Anti-MSH2 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y050845 |
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